1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Table 3

Modulation of ROS formation in BAECs by CA (DHPs and verapamil) and vitamin E. Compiled according to data presented by Cominacini et al. [123].

Compound	Method of flow cytometry (reduced 2,7-dichlorofluorescein diacetate (DCFH-DA) oxidation by ROS)
	Activity rank order; (ARO = I for the highest activity; ARO = III for the mindest activity); (Effective [IC]: 1; 5; 10; 50 M)
Lacidipine	+ + + (ARO = I)
Lercanidipine	+ + (ARO = II)
Amlodipine	No effect
Nifedipine	No effect
Nimodipine	No effect
Verapamil	+ (ARO = III)
-Tocopherol	+ + + (ARO = I)