Review Article

1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Table 5

Antiproliferative effect (oxLDL-induced HUVSMCs proliferation) of CA DHPs and simultaneous oxLDL-induced ROS production scavenging. Comparison with N-acetyl-L-cysteine, NAC (intracellular ROS scavenger). Compiled according to data presented by Zou et al., 2012 [130].

DHP compoundMethods
  Antiproliferative effect against proproliferative effect
 induced by oxLDL (50 g/mL) (UV detection of
  formazan production from tetrazolium salt)
  oxLDL-induced ROS production (fluorescent DCF
  (2′,7′-dichlorofluorescein) production)
Effective [IC] in M and I in %

Amlodipine3 MI = 18%3 M; 10 M No effect
I = 20%
S(−)-AmlodipineNo effect No effect
Lacidipine10 M;
30 M
I = 21%
I = 27%
10 MI~2/3 of control
N-Acetyl-L-cysteine, NAC 5000 M
(5 mM)
I = 28%