Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1

Figure 4

Glycyrrhizin normalized the dysregulated p66shc expression in AGEs treated late EPCs and the dysregulated SOD activity in cell culture supernatants. (a) The increased p66shc expression induced by AGEs was abrogated by glycyrrhizin treatment. (b) Treatment of late EPCs with glycyrrhizin reversed the decreased SOD activity induced by AGEs. (c) Glycyrrhizin attenuated the AGE-induced decrease in sirt1 expression in late EPCs. versus control group, versus control group, versus AGEs group, and versus AGE group, . Gly: glycyrrhizin.

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