Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2016 / Article

Comment on “The Impact of Chronic Tobacco Smoking on Retinal and Choroidal Thickness in Greek Population”

  • Salih Uzun |
  •  Article ID 1958086 |
  •  Published 28 Jun 2016

Response to: Comment on “The Impact of Chronic Tobacco Smoking on Retinal and Choroidal Thickness in Greek Population”

  • Marilita M. Moschos | Eirini Nitoda | ... | Irini P. Chatziralli |
  •  Article ID 8075360 |
  •  Published 01 Sep 2016
  • | View Article

Letter to the Editor | Open Access

Volume 2016 |Article ID 1958086 | https://doi.org/10.1155/2016/1958086

Salih Uzun, "Comment on “The Impact of Chronic Tobacco Smoking on Retinal and Choroidal Thickness in Greek Population”", Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 1958086, 1 page, 2016. https://doi.org/10.1155/2016/1958086

Comment on “The Impact of Chronic Tobacco Smoking on Retinal and Choroidal Thickness in Greek Population”

Academic Editor: David Pattison
Received23 Mar 2016
Accepted12 May 2016
Published28 Jun 2016

We have read the article entitled “The Impact of Chronic Tobacco Smoking on Retinal and Choroidal Thickness in Greek Population” by Moschos et al. [1] with interest. We congratulate the authors for demonstrating that the choroidal thickness (CT) and ganglion cell complex (GCC) thickness were significantly reduced in smokers when compared to the control group. We would like to ask for further details and contribute to the article.

Advancements particularly in optical coherence tomography (OCT) technology enabled high-resolution and noninvasive imaging of the retina and choroid. A number of local and physiological/pathological conditions may affect CT [2]. On the other hand, CT shows a significant diurnal variation. It increases at night and gets thinner later in the day. Tan et al. demonstrated the highest mean CT as 372.2 μm, which occurred at 9 AM [3]. The mean CT then decreased progressively over the subsequent time points to a low of 340.6 μm at 5 PM.

Usui et al. studied subfoveal choroidal thickness (SFCT) in healthy subjects and measured SFCT every 3 hours over a 24-hour period [4]. They found that the mean SFCT was the thinnest (μm) at 6 PM, and it was the thickest (μm) at 3 AM. In that study, Usui et al. showed that diurnal variation of CT might be up to 65 μm (range, 8–65 μm).

However, in their study, Moschos et al. did not mention the time at which OCT was obtained. Therefore, one might expect that physiological fluctuation would have significantly affected the test results and hence the statistical analysis. We recommend performing OCT measurements at the same time point, every day.

Competing Interests

The author declares no competing interests.

References

  1. M. M. Moschos, E. Nitoda, K. Laios, D. S. Ladas, and I. P. Chatziralli, “The impact of chronic tobacco smoking on retinal and choroidal thickness in Greek population,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 2905789, 7 pages, 2016. View at: Publisher Site | Google Scholar
  2. D. L. Nickla and J. Wallman, “The multifunctional choroid,” Progress in Retinal and Eye Research, vol. 29, no. 2, pp. 144–168, 2010. View at: Publisher Site | Google Scholar
  3. C. S. Tan, Y. Ouyang, H. Ruiz, and S. R. Sadda, “Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography,” Investigative Ophthalmology and Visual Science, vol. 53, no. 1, pp. 261–266, 2012. View at: Publisher Site | Google Scholar
  4. S. Usui, Y. Ikuno, M. Akiba et al., “Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects,” Investigative Ophthalmology & Visual Science, vol. 53, no. 4, pp. 2300–2307, 2012. View at: Publisher Site | Google Scholar

Copyright © 2016 Salih Uzun. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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