t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway

Figure 1

t-BHQ alleviates PbAc-induced alterations in redox status in the hippocampus and frontal cortex. Rats pretreated with t-BHQ (150 mg/kg) or corn oil for three days by oral gavage then cotreated with varies doses (10, 30 or 60 mg/kg) PbAc for five days by intraperitoneal injection (ip). The levels of MDA (a), SOD activity (b), and GSH content (c) were detected in these eight groups in the hippocampus and frontal cortex. in each group. Data represent the mean ± SEM of the results. and represent significant differences compared with the control group (corn oil without PbAc). and represent significant differences between two groups with or without t-BHQ treatment at the same concentration of PbAc.

(a)

(b)

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