t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway
Administration of t-BHQ protects rats against PbAc toxicity. (a) Nissl staining of rat brain sections was applied to investigate the histomorphology of cells in the hippocampus CA1 region and frontal cortex. The injured neurons (arrows) were characterized by cytoplasmic shrinkage, nuclear pyknosis, or hyperchromasia. Scar bar = 50 μm. The ratios of death neuroes/total neuroes were caculated and analyzed in these two regions, respectively. Data were collected from four fields of view. (b) The proapoptotic protein of Bax and antiapoptotic protein of Bcl2 were detected in the hippocampus and frontal cortex; immunoblots were quantified, respectively. in each group. Data represent the mean ± SEM of the results. and represent significant differences compared with the control group. and represent significant differences between two groups with or without t-BHQ treatment at the same concentration of PbAc (60 mg/kg).
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