Research Article

Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

Figure 2

STZ-induced diabetes enhances oxidative stress in rats subjected to ischemia AKI. Kidney tissues were collected to measure superoxide anion radical scavenging capacity (a), kidney superoxide dismutase (SOD) contents (b), and malondialdehyde (MDA) activity (c). The data in (a, b, c) are means ± SE (). versus NS group; versus DS group; versus NI/R group. NS and DS: nondiabetic and STZ-induced diabetic rats were subjected to sham operation. NI/R and DI/R: nondiabetic and STZ-induced diabetic rats were subjected to 25 min ischemia followed by 48 h reperfusion. DI/R-RES: STZ-induced diabetic rats that underwent I/R were treated with RES (10 mg/kg, ip daily) for 7 consecutive days before renal ischemia-reperfusion.
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