Oxidative Stress and Treg and Th17 Dysfunction in Systemic Lupus Erythematosus

Figure 4

Oxidative stress and Th17/Treg imbalance in SLE patients. Under the normal stage, Th17 cells and Treg cells stay in a dynamic immune balance. Increased oxidative stress was induced in SLE patients, which can further induce and expand the proinflammatory Th17 cells and inhibit the anti-inflammatory Treg cell differentiation and aggravate autoimmune injuries.