HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation

Figure 3

HSP27 reduces fibrosis deposition in interstitial myocardium of old mice. The hearts collected from 24-month-old mice were prepared for paraffin-embedded sectioning. Masson’s trichrome staining was performed on the sections to evaluate the fibrosis (indicated by arrows). Higher magnification images of the boxed areas are shown in the down panels. Representative images from three independent experiments are shown (a). The quantification of fibrosis was shown (b). versus WT controls. per group.

(a)

(b)