NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer

Figure 1

Regulation of NRF2 stability by KEAP1. NRF2 is constantly degraded by KEAP1-mediated ubiquitination in the cytoplasm. Oxidative stress will halt degradation of NRF2 and lead it to bind to ARE to activate transcription of oxidant and detoxifying enzymes.