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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 2768365, 9 pages
Review Article

Oxidative Stress Related Diseases in Newborns

Department of Pediatric Infectious Diseases, Hacettepe University, Faculty of Medicine, 06100 Ankara, Turkey

Received 25 March 2016; Revised 27 April 2016; Accepted 18 May 2016

Academic Editor: Serafina Perrone

Copyright © 2016 Yasemin Ozsurekci and Kubra Aykac. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage caused by oxidative stress seems to be a probable contributing factor to the pathogenesis of many newborn diseases, such as respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. We share the hope that the new understanding of the concept of oxidative stress and its relation to newborn diseases that has been made possible by new diagnostic techniques will throw light on the treatment of those diseases.