Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer

Table 2

Distribution of COMT G158A (rs4680) polymorphism in cervical cancer cases and controls.

COMT rs4680	OR [95% CI]
	Controls	Cervical cancer		OR crude	OR adjusted
	HH	79 (50.3)						48 (44.4)	0.003	0.79 [0.48–1.29]	0.31 [0.15–0.65]	0.347	0.002
HL	63 (40.1)	34 (31.5)	0.69 [0.41–1.14]	1.10 [0.55–2.19]	0.152	0.798
LL	15 (9.6)	26 (24.1)	3.00 [1.50–5.99]	4.83 [2.08–11.20]	0.002	<0.001
H	221 (70.0)	130 (60.0)	0.015	0.64 [0.44–0.92]	0.34 [0.21–0.56]	0.015	<0.001
L	93 (30.0)	86 (40.0)		1.57 [1.09–2.26]	2.93 [1.80–4.78]	0.015	<0.001

The values for the genotypes and respective allele frequencies represent absolute frequencies (relative frequencies, %). : test values; OR: odds ratio; : values for OR crude; : values adjusted for age (regression binary logistic); values statistically significant for value < 0.05.