Research Article
Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer
Table 3
Comparison of estradiol levels between controls and cervical cancer cases for different models of CYP1A1 (rs4646904) and COMT (rs4680) polymorphisms.
| CYP1A1&COMT rs4646903/rs4680 | Controls | Cervical cancer | |
| Estradiol (pg/mL) | 95 (7.17 ± 0.77) [0.95–31.64] | 28 (48.71 ± 12.35) [1.19–212.39] | <0.001 |
| CYP1A1 TT | 70 (6.80 ± 0.89) [0.95–31.64] | 16 (50.66 ± 17.56) [1.19–212.39] | <0.001 | CYP1A1 TC&CC | 15 (7.62 ± 1.53) [1.87–17.90] | 12 (46.14 ± 17.57) [19.53–189.76] | <0.001 |
| COMT HH&HL | 73 (8.46 ± 6.39) [0.95–412.22] | 19 (47.66 ± 33.11) [1.19–641.15] | <0.001 | COMT LL | 11 (8.19 ± 27.32) [2.43–272.39] | 4 (99.09 ± 176.48) [21.00–764.57] | 0.037 |
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The values represent (median ± standard error) [min.–max.]. : Mann-Whitney test; values statistically significant for value < 0.05.
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