Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer

Table 3

Comparison of estradiol levels between controls and cervical cancer cases for different models of CYP1A1 (rs4646904) and COMT (rs4680) polymorphisms.

CYP1A1&COMT; rs4646903/rs4680	Controls	Cervical cancer
Estradiol (pg/mL)	95 (7.17 ± 0.77) [0.95–31.64]	28 (48.71 ± 12.35) [1.19–212.39]	<0.001
CYP1A1 TT	70 (6.80 ± 0.89) [0.95–31.64]	16 (50.66 ± 17.56) [1.19–212.39]	<0.001
CYP1A1 TC&CC	15 (7.62 ± 1.53) [1.87–17.90]	12 (46.14 ± 17.57) [19.53–189.76]	<0.001
COMT HH&HL	73 (8.46 ± 6.39) [0.95–412.22]	19 (47.66 ± 33.11) [1.19–641.15]	<0.001
COMT LL	11 (8.19 ± 27.32) [2.43–272.39]	4 (99.09 ± 176.48) [21.00–764.57]	0.037

The values represent (median ± standard error) [min.–max.].
: Mann-Whitney test; values statistically significant for value < 0.05.