Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer

Table 4

Represents the cumulative effects of association of CYP1A1 M1 and COMT polymorphisms between cervical cancer cases and controls.

CYP1A1&COMT rs4646903/rs4680	OR [95% CI]
	Controls	Cervical cancer	OR crude	OR adjusted
Other genotypes	45 (44.6)	64 (77.1)	4.19 [2.20–7.99]	5.68 [1.88–17.13]	<0.001	0.002
Protection model  TT&HL	56 (55.4)	19 (22.9)	0.24 [0.13–0.46]	0.18 [0.06–0.53]
Other genotypes	98 (97.0)	70 (84.3)	0.17 [0.05–0.60]	0.13 [0.01–1.31]	0.006	0.083
Risk model  TC&HL	3 (3.0)	13 (15.7)	6.07 [1.67–22.09]	7.65 [0.76–76.49]

The values for the genotypes represent absolute frequencies (relative frequencies, %). OR: odds ratio; : values for OR crude; : values adjusted for age (regression binary logistic); values statistically significant for value < 0.05.
In protection model, the other genotypes represent (b) TT&LL, TC&LL, CC&HL, TT&HH, TC&HL, TC&HH; CC&HH, and CC&LL.
In risk model, the other genotypes represent (c) TT&HL, TT&LL, TC&LL, CC&HL, TT&HH, TC&HH, CC&HH, and CC&LL.