Review Article

The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

Figure 2

Involvement of ROS in regulating M2 responsible inflammation resolving and wound healing activities. Multiple pathways are involved in reducing NADPH and its oxidase followed by reduced ROS generation. The low ROS level was accompanied by reduced inflammatory mediators; increased M2-regulated genes responsible for inflammation resolution; and increased disulphide protein degradation which enhanced wound healing effect of M2. S7P, sedoheptulose-7-phosphate; sedo, sedoheptulose; PPP, pentose phosphate pathway; SYNCRIP, synaptotagmin binding, cytoplasmic RNA interacting protein; SOD, superoxide dismutase.