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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 3075695, 9 pages
Review Article

Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives

Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health Care of Russian Federation, 15a 3rd Cherepkovskaya Street, Moscow 121552, Russia

Received 22 December 2015; Revised 16 February 2016; Accepted 16 March 2016

Academic Editor: Tanea T. Reed

Copyright © 2016 Alexander V. Maksimenko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Undiminishing actuality of enzyme modification for therapeutic purposes has been confirmed by application of modified enzymes in clinical practice and numerous research data on them. Intravenous injection of the superoxide dismutase-chondroitin sulfate-catalase (SOD-CHS-CAT) conjugate in preventive and medicative regimes in rats with endotoxin shock induced with a lipopolysaccharide bolus has demonstrated that antioxidant agents not only effectively prevent damage caused by oxidative stress (as believed previously) but also can be used for antioxidative stress therapy. The results obtained emphasize the importance of investigation into the pathogenesis of vascular damage and the role of oxidative stress in it. The effects of intravenous medicative injection of SOD-CHS-CAT in a rat model of endotoxin shock have demonstrated a variety in the activity of this conjugate in addition to prevention of NO conversion in peroxynitrite upon interaction with superoxide radical. Together with the literature data, these findings offer a prospect for the study of NO-independent therapeutic effects of SOD-CHS-CAT, implying the importance of a better insight into the mechanisms of the conjugate activity in modeled cardiovascular damage involving vasoactive agents other than NO.