Research Article

24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-β1 Signaling Pathway in Sprague-Dawley Rats Model

Table 3

Effects of O-Tyr on body weight (g), liver weight (g), and liver index (mg/g) ().

ParametersControlO-Tyr (2 g/kg)O-Tyr (4 g/kg)O-Tyr (8 g/kg)Tyr (8 g/kg)

Initial body weight349.56 ± 10.24345.13 ± 16.83340.53 ± 10.46351.67 ± 4.18343.20 ± 8.35
Final body weight734.98 ± 22.45722.64 ± 26.68 637.18 ± 20.04591.88 ± 13.34728.96 ± 23.51
Liver16.78 ± 0.8316.63 ± 0.7515.88 ± 0.8817.09 ± 1.0216.03 ± 1.10
Liver index22.83 ± 0.4823.01 ± 0.6324.92 ± 0.7728.87 ± 1.1623.34 ± 0.84

Notes: and versus rats in the control group, the same as Tables 4 and 5.