24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-β1 Signaling Pathway in Sprague-Dawley Rats Model

Table 4

Effects of O-Tyr on hepatotoxicity and hepatic fibrosis indexes of rats ().

Parameter	Control	O-Tyr (2 g/kg)	O-Tyr (4 g/kg)	O-Tyr (8 g/kg)	Tyr (8 g/kg)
Serum
AST (U/L)	143.40 ± 5.26	151.12 ± 8.34	161.88 ± 5.60	168.81 ± 6.38	140.17 ± 8.08
ALT (U/L)	39.02 ± 2.78	43.26 ± 3.11	47.54 ± 2.08	52.56 ± 2.33	40.33 ± 3.56
TBiL (μmol/L)	3.34 ± 0.18	3.90 ± 0.25	5.02 ± 0.33	7.13 ± 0.45	3.28 ± 0.59
Liver
I CTP (μg/mg protein)	8.34 ± 0.23	8.25 ± 0.21	9.63 ± 0.44	10.24 ± 0.32	8.11 ± 0.20
PIIINP (μg/mg protein)	7.56 ± 0.34	8.62 ± 0.19	9.54 ± 0.33	10.87 ± 0.43	7.79 ± 0.47