24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-β1 Signaling Pathway in Sprague-Dawley Rats Model

Table 5

Effects of O-Tyr on mRNA expression fibrosis-related genes in rats liver ().

Genes	Control	O-Tyr (2 g/kg)	O-Tyr (4 g/kg)	O-Tyr (8 g/kg)	Tyr (8 g/kg)
p38	1.00 ± 0.23	2.34 ± 0.56	4.90 ± 0.53	6.73 ± 0.92	1.28 ± 0.34
ERK2	1.00 ± 0.23	4.56 ± 0.78	5.25 ± 0.42	8.66 ± 0.89	1.00 ± 0.27
TGF-β1	1.00 ± 0.34	4.72 ± 0.89	8.17 ± 0.94	11.01 ± 1.67	0.97 ± 0.42
Smad2	1.00 ± 0.28	3.23 ± 0.56	4.61 ± 0.83	7.55 ± 0.45	1.19 ± 0.38
Smad3	1.00 ± 0.16	4.44 ± 0.82	6.02 ± 0.74	8.57 ± 0.93	1.32 ± 0.44