Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression

Figure 1

Histopathological staining of grafted vessels and analysis of cell proliferation and apoptosis under light microscopy (original magnification ×200). (a1)–(a3) Hematoxylin-eosin (HE) staining of grafted aortic specimens obtained 8 weeks after transplantation. (b1)–(b3) Immunohistochemical staining of Ki-67 in arterial grafts. (c1)–(c3) Immunohistochemical staining of caspase-3 in grafted arteries. (d1) Thickness of intima in each group (μm, original magnification ×200), , allograft group compared with the isograft group; , lycopene group compared with the allograft group. (d2) The positive cells ratio of Ki-67/caspase-3 in each group, , . ((a1), (b1), and (c1)) Isograft group; ((a2), (b2), and (c2)) allograft group; ((a3), (b3), and (c3)) lycopene group.