Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver through α-Adrenergic Signaling

Figure 5

Effect of α- or β-adrenergic blocker on CCl₄ induced hepatic injury and oxidative DNA damage. Histological features (a) and area of necrosis (b) of liver sections stained with hematoxylin and eosin 24 h after CCl₄ treatment. Typical images were selected from each experimental group (original magnification 200x). The saline + CCl₄ group showing hepatocellular necrosis; the phentolamine + CCl₄ group showing mild hepatocellular necrosis. (c) Oxidized DNA in liver was measured 24 hours after exposure to CCl₄ following pretreatment with saline, phentolamine, or nadolol. Data plotted are mean and SD ( animals in each group).   denotes significant differences () compared with the saline + CCl₄ group.   denotes significant differences () compared with the saline + CCl₄ group.

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