Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver through α-Adrenergic Signaling

Table 2

Hepatic lipid peroxidation and serum biochemical markers in mice after 24 hours of CCl₄ treatment with or without pretreatment of -adrenergic blocker or -adrenergic blocker.

Parameter	Saline + CCl4; ( = 4)	Phentolamine + CCl4; ( = 4)	Nadolol + CCl4; ( = 4)
4-Hydroxy-2-nonenal (4-HNE, g/g protein)	0.34 ± 0.04	0.25 ± 0.01	0.28 ± 0.02
Aspartate transaminase (AST, IU/L)	16,695 ± 5,203	6,038 ± 3,320	13,571 ± 5,758
Alanine transaminase (ALT, IU/L)	14,559 ± 3,268	7,318 ± 3,799	10,830 ± 4,381
Alkaline phosphatase (ALP, IU/L)	131 ± 14	106 ± 21	140 ± 31
Lactate dehydrogenase (LDH, IU/L)	30,656 ± 9,387	8,994 ± 5,986	17,483 ± 10,584

The results are presented as mean ± SD.
denotes significant differences compared with the saline + CCl₄ group ().