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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 3419479, 8 pages
Research Article

Effect of Caffeic Acid Phenethyl Ester on Vascular Damage Caused by Consumption of High Fructose Corn Syrup in Rats

1Department of Pharmacology, Faculty of Medicine, Firat University, Elazığ, Turkey
2Department of Pharmacology, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey
3Department of Biochemistry, Vocational School of Health Services, Adıyaman University, Adıyaman, Turkey
4Department of Histology, Faculty of Medicine, Firat University, Elazığ, Turkey
5Department of Biochemistry, Faculty of Veterinary, Firat University, Elazığ, Turkey

Received 24 April 2015; Accepted 8 February 2016

Academic Editor: Vittorio Calabrese

Copyright © 2016 Aburrahman Gun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE) has beneficial effects on metabolic syndrome and vascular function which is important in the prevention of cardiovascular disease. However, there are no known studies about the effect of CAPE on fructose-induced vascular dysfunction. In this study, we examined the effect of CAPE on vascular dysfunction due to high fructose corn syrup (HFCS). HFCS (6 weeks, 30% fed with drinking water) caused vascular dysfunction, but treatment with CAPE (50 micromol/kg i.p. for the last two weeks) effectively restored this problem. Additionally, hypertension in HFCS-fed rats was also decreased in CAPE supplemented rats. CAPE supplements lowered HFCS consumption-induced raise in blood glucose, homocysteine, and cholesterol levels. The aorta tissue endothelial nitric oxide synthase (eNOS) production was decreased in rats given HFCS and in contrast CAPE supplementation efficiently increased its production. The presented results showed that HFCS-induced cardiovascular abnormalities could be prevented by CAPE treatment.