Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice

Figure 2

Infarct area and LDH release. Hearts from mice fed for 12 weeks with Control or HFHF diet, exposed to 30-minute ischemia plus 60-minute reperfusion. (a) Infarct size in the basal part of the ventricle after IR exposition is expressed as a percentage of ischemic tissue (%IS/IT). (b) LDH release in the perfusion effluent during the IR was expressed as units per mg of wet tissue weight. versus Control.

(a)

(b)