Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice
Prosurvival RISK pathway activation in the mouse heart. Representative western blotting for cardiac levels of total ERK1/2 expression and Thr202/Tyr204 phosphorylation, respectively, (a), total Akt protein expression and Ser473 phosphorylation (b), and total GSK-3 protein expression and Ser9 phosphorylation (c) performed on heart apex extracts from Control or HFHF diet mice, exposed or not to IR. Histograms report densitometric analysis of the phosphorylated-to-total form ratio of 5-6 mice per group. versus Control; versus Sham.
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