Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?

Figure 1

Effects of changing the oxidative status on cytoplasmic and mitochondrial enzymes from liver slices from control and PH rats. In panel (a), results of released ALT and LDH (cytoplasmic enzymes) are expressed as mean ± SE of six individual observations per experimental point. In panel (b), results of release of MDH and AST (enzymes sharing cytoplasmic and mitochondrial localization) are expressed and, in panel (c), those of the release of OCT and GDH activities (mitochondrial enzymes) are expressed. Enzyme release was tested under basal conditions. Abbreviations for the compounds used: hydrogen peroxide (H₂O₂) and butylated hydroxytoluene (BHT). Statistical significance: against the group of sham-operated controls (basal conditions); versus PH rats group (basal conditions).

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