Protective Effect of Peroxisome Proliferator-Activated Receptor α Activation against Cardiac Ischemia-Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3
WY-14643 decreased myocardial infarct size. WY-14643 20 mg/kg was administered 4 h before the occlusion of left anterior descending coronary artery. (a) Area at risk was similar between the groups. (b) WY-14643 decreased the percentage of myocardial infarct size to area at risk. versus control (c) Representative pictures of stained myocardial sections.
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