PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model

Figure 1

Time-course western blot analysis of p-ERK1/2 in cerebral ischemia reperfusion at 12 h, 24 h, 48 h, and 72 h. (a) Representative western blot. (b) Phosphorylation of ERK1/2 ratios (phosphorylated versus total protein). The phosphorylation of ERK1/2 increased significantly in all rats within 24 h after CA/PCR compared to sham group (). Compared to CA group, treatment with PD98059 significantly reduced phosphorylation of ERK1/2 from 48 h to 72 h of PCR, ; mean ± standard deviation. for each group (A = versus the sham group; B = versus the CA group).

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