Oxidative Medicine and Cellular Longevity / 2016 / Article / Tab 1

Review Article

Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart

Table 1

Regulation of miRNAs in hyperlipidemia.

miRNARegulation of miRNAOrganTargetRegulation of targetRoleReferences

let-7gdownAortaox-LDL receptor 1upox-LDL cholesterol uptake[24]
miR-25downHeartNOX4upOxidative stress[8]
miR-33upLiver, macrophagesABCA1down Reverse cholesterol transport[25]
miR-33upPeripheral tissuesABCG1down Reverse cholesterol transport[25, 26]
miR-33downLiverFatty acid synthesisdown VLDL synthesis [27]
miR-33downLiverFatty acid oxidationupVLDL synthesis [27]
miR-144upLiverABCA1down Reverse cholesterol transport[28]
miR-223upLiverHMG-CoA synthase 1down Cholesterol biosynthesis[29]
miR-223upLiverScavenger receptor B1down HDL cholesterol uptake[29]
miR-208aupHeartMED13down Glucose tolerance[30]
miR-378 and miR-378upLiverMED13downGlucose tolerance[31]
miR-378 and miR-378upInsulin dependent tissuesFatty acid oxidationdownObesity[31]

ABC: ATP-binding cassette transporter; HDL: high density lipoprotein; VLDL: very low density lipoprotein; MED: mediator complex subunit; NOX: NADPH oxidase.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.