The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species
ROS stimulation induces translocation of Nrf2 to the nucleus and autophagy in PANC-1 cells. (a) The expression of Nrf2, Beclin1 and LC3-II and also the level of p62 in PANC-1 cells under basal condition and upon ROS stimulation. (b–d) Immunofluorescence images of PANC-1 cells for Nrf2, Beclin1 and LC3 under basal condition and upon ROS stimulation. (e) Numbers of autophagosomes per cell were counted in 10 random fields. The data are presented as Mean ± SD for three independent experiments. Column: Mean; bar: SD.