Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation

Figure 1

HIRI after 60 minutes of ischemia followed by 6 hours of reperfusion in control or diabetic rats. ((a), (b)) Hepatic pathological sections (200x) and pathology score by Suzuki’s criteria. ((c), (d)) Serum ALT and AST levels. Measurable data are expressed as mean ± SEM ( per group). Pathology scores are expressed as medium with interquartile range. versus diabetic sham group; versus diabetic sham group; versus normal HIRI group. HIRI: hepatic ischemia reperfusion injury; ALT: alanine aminotransferase; AST: aspartate aminotransferase; sham: sham operating group.

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