Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment

Figure 2

Analysis of mitochondrial content. (a)-(b) Electron microscopic view of ultrathin sections of MCF-10A (a) and MDA-MB-231 cells (b). See supplemental Figure for images at a higher magnification. The letter “N” denotes nucleus, and the rectangles indicate mitochondria that show high (distinctly darker) (a) and low (b) electron density. (c) Count of mitochondrial numbers using electron microscopy, with median values indicated; . (d) Western blot analysis of mitochondrial proteins complex I (C1), complex III (C3), and VDAC. (d) Densitometric analysis of western blot images as shown in (d) (–5). and .

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