Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo

Figure 6

Morphologic distribution and quantitative estimation of renal CaOx crystals. ((a)–(c)) Representative micrographs of renal sections and crystal deposits were presented in the control group, the EG treated group, and the EG + metformin treated group, respectively, using HE staining and polarized light optical microphotography. Original magnification, ×100 in inset. ((d)–(f)) Representative micrographs of the control group, the EG treated group, and the EG + metformin treated group, respectively. Original magnification, ×400 in inset. (g) The ratios of areas with renal crystal deposition per low-powered field were estimated. (h) Grade of calcium oxalate deposits per high-powered field was assessed. , versus the EG treated group.

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