Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury

Figure 1

Antioxidant treatment reduces the blast-induced accumulation of somatic Tau in the hippocampus. Representative images of normal Tau (Tau-1) staining in the polymorphic layer of the dentate gyrus (PoDG) of the hippocampus from normal controls ((a) and (d)) and from untreated ((b) and (e)) or antioxidant-treated ((c) and (f)) rats seven days following blast trauma. The rectangles in (a)–(c) indicate the locations from which images were collected for (d)–(f), respectively. Cells positive for somatic Tau-1 immunostaining were observed in the hippocampus of all three groups, albeit rarely in normal controls (arrows in (a)–(f)). Scale bars = 200 μm in (c) for (a)–(c) and = 20 μm in (f) for (d)–(f). GrDG, granular layer of the dentate gyrus; MoDG, molecular layer of the dentate gyrus.

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