Review Article

ROS and ROS-Mediated Cellular Signaling

Figure 4

Cross talk between ROS and Keap1-Nrf2-ARE signaling pathway. Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; ARE, antioxidant response elements; Cul3, cullin-3 E3-ubiquitin ligase; GSK3β, glycogen synthase kinase 3; Ubc, E2-ubiquitin conjugating enzyme.