S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway

Figure 2

The antioxidant effect of SPRC on hepatic ROS level, MDA level, SOD activity, and lipid content in the livers of NAFLD mice fed MCD diet. Mice fed a MCD diet were treated with SPRC (20, 40, and 80 mg/kg/d) and SPRC+PAG for four weeks. (a) The effect of SPRC on hepatic ROS level. Photomicrographs were taken at ×100 magnification. (b) The effect of SPRC on hepatic MDA level. (c) The effect of SPRC on hepatic SOD activity. (d) The effect of SPRC on hepatic TG level. (e) The effect of SPRC on hepatic TC level. (f) Representative images for the liver stained by H&E (original magnification, ×200; scale bar = 250 μm). Data shown are means ± SEM; compared with MCS diet control group, ; compared with MCD diet control group, ; compared with MCD+SPRC 40 mg/kg/d+PAG group, .

(a)

(b)

(c)

(d)

(e)

(f)