Equine Metabolic Syndrome Affects Viability, Senescence, and Stress Factors of Equine Adipose-Derived Mesenchymal Stromal Stem Cells: New Insight into EqASCs Isolated from EMS Horses in the Context of Their Aging

Figure 9

EqASC mRNA levels of p21, p53, BAX, caspase-9, and the BCL-2/BAX ratio. Gene expression in the EqASC culture. The upregulation of apoptotic-related genes observed in results in decreased proliferation potential and senescence phenotype. BAX and CAS-9 increased expression suggest that those cells undergo apoptosis via mitochondrial pathway. mRNA levels of p21 (a), p53 (b), BAX (c), and caspase-9 (d). The ratio between BCL-2 and BAX expression in each group estimated by dividing Qn of BCL-2 by Qn of BAX (e). Results expressed as mean ± SD. value < 0.05; value < 0.01.

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