The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?

Table 1

Screening of cytotoxic effect of SSe (2–10 M) and -TOS (20–100 M) and their combination with 2 M and 10 M SSe and the resultant combination indices after 48 hours on MCF7 cells. The results are obtained from 5 independent experiments performed in triplicate.

Human; cancer cell lines	The 50% inhibitory concentration				Combination index (CI)
	TOS (μM)	SSe (μM)	TOS + 2 μM SSe	TOS + 10 μM SSe	TOS + 2 μM SSe	TOS + 10 μM SSe
HeLa	>100	>10	>100	>100	1.05	2.37
A549	82	>10	90.5	>100	1.86	2.19
T47D	>100	>10	>100	>100	1.42	2.24
PC3	>100	>10	>100	>100	1.50	2.38
HepG2	83.3	>10	93.2	98.2	2.08	3.07
HCT-116	76.8	>10	89.8	91.3	1.25	2.22
MCF7	57.5	5.45	65.5	12.5	1.50	2.09