Memory Deficit Recovery after Chronic Vanadium Exposure in Mice

Figure 3

Effect of intermittent vanadium (VAN) treatment for nine months on learning and memory in mice: 12 male mice were exposed thrice a week for nine months to VAN (3 mg/kg b.w.) with equal number and age matched controls. The withdrawal group were exposed to VAN for three months but replaced with water thereafter. All the groups of the 9-month-old rats (C9, VAN9, and W6) were able to learn the location of the hidden platform with no statistically significant difference among them (a). However, there was a statistically significant decrease in memory retention in vanadium () and withdrawal () groups relative to control ((b) and (c)). The W6 group showed some recovery ((b) and (c)) in comparison to the VAN9 group but was still significantly less than the controls.

(a)

(b)

(c)