Memory Deficit Recovery after Chronic Vanadium Exposure in Mice

Figure 4

Effect of intermittent vanadium (VAN) treatment for twelve months on learning and memory in mice: 12 male mice were exposed thrice a week for twelve months to VAN (3 mg/kg b.w.) with equal number and age matched controls. The withdrawal group were exposed to VAN for three months but replaced with water thereafter. All the groups of the 12-month-old rats (C12, V12, and W9) were able to learn the location of the hidden platform with no statistically significant difference among them. However, there was statistically significant decrease in memory retention in V12 ( and ) relative to controls ((b) and (c)). The W9 group showed a remarkable recovery in memory retention being significantly higher () than the V12 (b) and were comparable to the controls.

(a)

(b)

(c)