Protective Role of Dietary Curcumin in the Prevention of the Oxidative Stress Induced by Chronic Alcohol with respect to Hepatic Injury and Antiatherogenic Markers

Figure 4

Influence of chronic ethanol and curcumin on serum PON1 and homocysteine thiolactonase activities were measured in rats fed low and high ω-3 PUFA diets. The animals in the indicated groups () were pair-fed their respective Lieber-DeCarli alcohol containing liquid diets supplemented with the indicated concentration of the curcumin for 8 weeks after which the animals were killed and serum sample was analyzed. (a) Serum PON1 activity measured using paraoxon as substrate. (b) Serum homocysteine thiolactonase activity was measured using γ-thiobutyrolactone as substrate. Enzyme activities in the various experimental groups are expressed as percent of the corresponding values in the LFO group. The data are Means ± SEM. Statistical significance of variance was calculated using t-test with Bonferroni correction; compared to LFO group; compared to LFO group; compared HFOE group.

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