Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function

Figure 6

Effect of endothelial MPs on endothelium-dependent vasorelaxation in isolated mesenteric arteries. (a) Concentration-response curve to acetylcholine in untreated control vessels, those incubated with endothelial MPs (10⁵/mL, 30 minutes) or those incubated with endothelial MPs pretreated with the NADPH oxidase inhibitor apocynin (Apo MPs, 10⁵/mL, 30 minutes). versus control vessels at corresponding dose, –8. (b) Sensitivity to acetylcholine (expressed as pD2 ). versus control, –8.

(a)

(b)