Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetes Mellitus in Rats: Role of Alhagi maurorum Extracts
Light micrographs of pancreatic sections of the following. (A) Control rats revealed normal pancreatic architecture; the closely packed pancreatic acini composed of pyramidal shaped cells with rounded nuclei (a), the pale-stained normal islets of Langerhans (IS) scattered in between acini with well-preserved cytoplasm, and nucleus normal interlobular connective tissue septa (red arrow). B1, B2, and B3 represent STZ-diabetic group of rats and showed disturbance of the acinar pattern structure, pyknotic nuclei of some acini cells (black arrow) with severe damage; dilation and thickening of blood vessels (dashed arrow) and congestion of the blood vessels (red arrow) and vacuolated acini (green arrow). Islets with irregular outline, vacuolated cytoplasm (circle), and degeneration of -islet cells (green arrow). C and D represent STZ + WE- and STZ + EE-treated rats and showed a slight reduction in the histological alterations of the pancreatic acini only. H&E, 400x.
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