Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

<div>Mitochondrial biogenesis and energy metabolism evaluated in the rat hearts exposed to 30 min ischemia plus 20 or 60 min reperfusion, pretreated or not with INF4E. (a) Representative Western blotting for cardiac levels of MtTFA, NRF-1, and sMtCK performed on heart extracts. (b)–(d) Histograms report densitometric analysis normalized for the corresponding tubulin content. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways 

Figure 5 | Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways 