Research Article

Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice

Figure 9

Schematic diagram of LPS induced heart failure in young and aged mice. Aging led to oxidative damage which may induce autophagy, where autophagic response leads to less oxidative damage. Oxidative damage leads to inflammation and cell death and is more pronounced in aging. This leads to chronic injury and associated cardiac dysfunction or heart failure.