The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus

Table 1

Clinical characteristics, demographics, proinflammatory cytokines, oxidants, and antioxidants. In terms of the recipients, there were significantly more transplantations done in males than females. As a point of inclusion in the study the creatinine was found significantly elevated in AGD, as was urea. The significant older age of the donors could have influenced the AGD. It is attention-grabbing that the inflammatory state between AGD and N-AGD did not predominate. The oxidative state is characterized by significant increases in LPO and 8-IP in AGD and diminished NO and SOD activity.

	N-AGD	AGD
Demographic and metabolic characteristics
Age (years)
Weight (kg)
Height (m)
Gender F/M,	21/34 (38/62)	7/48 (13/87)	0.004
Glucose mg/dL
Urea mg/dL			<0.001
Cr habitual (mg/mL)			0.002
CT (mg/dL)
LDL (mg/dL)
HDL (mg/dL)
VLDL (mg/dL)
TAG (mg/dL)
Tobacco no/yes,	47/8 (85/15)	40/15 (73/27)
Alcoholism no/yes,	46/9 (83/17)	41/14 (76/24)
Donor age (years)			<0.001
Time after transplant (months)			<0.001
Proinflammatory cytokines
TNF-α (pg/mL)
IL-6 (pg/mL)
CRP mg/L,
≤3.19	36 (65.5)	34 (61.5)
>3.19	19 (34.5)	21 (38.5)
Oxidants
LPO (μM)			0.014
8-isoprostanes (pg/mL)			0.012
Nitric Oxide (μmol/L)			0.042
Antioxidants
SOD (U/mL)			0.012

AGD: acute graft dysfunction. Mean ± standard deviation or standard error, p = Mann–Whitney test, and test.