The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer

Figure 2

Distribution of some genotypes/alleles in patients with papillary urothelial neoplasms of low malignant potential (LMP, 11 samples) as compared to high grade carcinomas (high, 156 samples). Four coupled bars correspond to ERCC6 Met1097Val polymorphisms. The frequencies of the Met/Met genotype are 81.8% and 49.4% in LMN and high grade tumors, whereas the frequencies of the Met/Val + Val/Val genotypes are 18.2% and 50.6% in the same types of urothelial carcinomas, respectively. The last coupled bars reflect the frequencies of the OGG1 (codon 326) heterozygous genotype, which are 54.5% in LMP neoplasms and 26.3% in high grade tumors.