The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer

Table 3

The cellular response to the oxidative stress in vitro in the case group as compared to controls.

Features under study	Exposure, time of lymphocyte incubation (min)	BC patients; ( = 40)	Controls/healthy donors; ( = 35)
Basal DNA damage	Intact lymphocytes
	180	11.4 ± 1.0	9.2 ± 0.8
Oxidatively induced DNA damage	Exposure to H2O2
	0	117.1 ± 7.1	85.6 ± 4.4^a
	30	41.8 ± 3.8	31.7 ± 3.2^a
	60	29.9 ± 2.7	22.8 ± 2.1^a
	180	17.7 ± 1.6	13.3 ± 1.1^a
DNA repair efficiency	30	65.2	63.0
	60	74.5	73.4
	180	84.3	84.4

Significant differences are observed between the levels of H₂O₂-induced DNA damage in BC patients and healthy controls ( = 0.00035, 0.045, 0.037, and 0.026 at 0, 30, 60, and 180 min after mutagenic exposure according to two sided Student's -test, and 0.01 < < 0.05 according to the nonparametric Mann-Whitney test).