Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 5743838, 5 pages
http://dx.doi.org/10.1155/2016/5743838
Research Article

Serum Lipoprotein (a) Levels in Black South African Type 2 Diabetes Mellitus Patients

Division of Medical Biochemistry, Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 5100, South Africa

Received 29 June 2016; Revised 8 September 2016; Accepted 25 September 2016

Academic Editor: Angel Catalá

Copyright © 2016 Jim Joseph et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lipoprotein (a) (Lp(a)) which is a low-density lipoprotein-like particle containing apo(a) is considered as an emergent cardiovascular risk factor. Type 2 diabetes mellitus (T2DM) is associated with a two- to threefold increase in the risk of cardiovascular disease (CVD). The aim of this study was to investigate the levels of Lp(a) in Black South African T2DM patients and its association with other metabolic factors. 67 T2DM patients and 48 healthy control participants were recruited for the cross-sectional study. The Lp(a) level was determined by ELISA and the result was analyzed using SPSS. The Lp(a) level in diabetics was found to be significantly increased () when compared to the normal healthy group. In the diabetic group, the Lp(a) levels correlated significantly with the duration of diabetes () and oxidized LDL (ox-LDL) levels () and decreased total antioxidant capacity (). The third tertile of Lp(a) was significantly correlated with increased ox-LDL, C-reactive protein, and triglycerides and decreased total antioxidant capacity.